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The Lash & Brow Growth Peptide Acetyl Tetrapeptide-11
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Product Description
1. Mechanism of Action (MOA)
Acetyl Tetrapeptide-11 is a biomimetic peptide specifically designed to enhance the appearance of eyelashes and eyebrows. Its mechanism is multi-factorial, targeting the hair follicle's health and growth cycle.
Stimulation of Keratinocyte Proliferation: It promotes the multiplication of keratinocytes, the primary cells that constitute the hair shaft, leading to the formation of a thicker and more robust hair fiber.
Prolongation of the Anagen (Growth) Phase: The peptide helps to extend the duration of the active growth phase of the hair cycle. This allows lashes and brows to grow longer before naturally shedding.
Increase in Hair Follicle Density: By improving the health and vitality of the hair follicle, it can help reduce premature shedding and increase the number of hairs in the growth phase simultaneously, resulting in a denser, fuller appearance.
Enhancement of Hair Fiber Strength: It contributes to the structural integrity of the hair, reducing breakage and making lashes and brows more resilient.
In summary, Acetyl Tetrapeptide-11 works by fundamentally optimizing the hair growth cycle and improving the quality of each individual hair, leading to visibly longer, thicker, and denser eyelashes and eyebrows.
2. In Vitro Efficacy Data
Models: Human hair follicle organ cultures, human keratinocyte cultures.
Key Findings:
Increased Keratinocyte Growth: Studies showed a significant, dose-dependent increase in the proliferation rate of human keratinocytes treated with Acetyl Tetrapeptide-11.
Prolonged Anagen Phase In Vitro: In cultured hair follicles, the peptide was shown to delay the transition to the catagen (regression) phase, effectively extending the growth period.
Upregulation of Growth Factors: It was found to stimulate the expression of key growth factors associated with hair follicle health and cycling.
3. Clinical Results
Human clinical studies have demonstrated its efficacy in improving the appearance of lashes and brows.
Eyelash Enhancement Study (12-16 weeks):
Method: A formula containing ~5 ppm Acetyl Tetrapeptide-11 was applied daily to the lash line. Parameters were measured via automated image analysis and expert grading.
Result: After 12-16 weeks of use, subjects exhibited a statistically significant increase in:
Eyelash Length (up to 20% increase)
Eyelash Density/Fullness (up to 15% increase)
Overall Lash Appearance
Eyebrow Enhancement Study:
Result: Similar studies focusing on eyebrows showed a visible improvement in brow density and coverage, particularly in sparse areas.
Consumer Self-Assessment:
Result: The vast majority of participants reported high satisfaction, noting their "lashes looked longer and thicker" and their "brows appeared fuller."
Safety Profile
Specifically designed for use in the sensitive eye area. It is non-irritating and non-sensitizing in recommended concentrations. It is considered a safe, cosmetic alternative to prostaglandin-analog-based lash growth products.
Compatibility
Synergistic Combinations:
*With Biotinoyl Tripeptide-1: Provides essential building blocks for keratin formation.
*With Hyaluronic Acid: Hydrates and conditions the hair follicle and surrounding skin.
*With Panthenol (Provitamin B5): Strengthens hairs and improves flexibility to prevent breakage.
Ideal for Sensitive Formulations: Its high safety profile makes it suitable for gentle, ophthalmologically-tested serums.
*With Biotinoyl Tripeptide-1: Provides essential building blocks for keratin formation.
*With Hyaluronic Acid: Hydrates and conditions the hair follicle and surrounding skin.
*With Panthenol (Provitamin B5): Strengthens hairs and improves flexibility to prevent breakage.
Ideal for Sensitive Formulations: Its high safety profile makes it suitable for gentle, ophthalmologically-tested serums.
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Recommended Usage & Formulation
Recommended Concentration: 3 - 10 ppm (0.0003% - 0.001%) in the final product.
Suitable Applications: Specifically formulated for targeted treatments.
Eyelash Growth Serums: The primary and most effective application.
Eyebrow Enhancing Serums & Gels: To fill in sparse brows and promote growth.
Conditioning Lash Primers: Can be incorporated into cosmetic products that coat the lashes.
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Clinically Proven Efficacy
Visible improvements in lash length, thickness, and density demonstrated in human studies.
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Multi-Targeted Action
Works by extending the growth phase, stimulating growth cells, and strengthening hair fibers.
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Safer Cosmetic Alternative
Offers a non-pharmacological, gentle approach to lash and brow enhancement compared to prostaglandin analogs.
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Targeted for Delicate Areas
Formulated with the safety of the eye area in mind.
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High Consumer Satisfaction
Meets the strong market demand for "clean" and effective lash and brow solutions.
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Synergistic Potential
Can be combined with other hair-conditioning and growth-supporting ingredients for enhanced results.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available